Glutathione Therapy in EdmontonOur Naturopaths are experienced with Glutathione Treatment.Many of our Vitamin treatments can be followed by Glutathione Glutathione is a potent antioxidant that interacts with reactive oxygen species & reactive nitrogen species. Glutathione’s mechanism of action involves enzyme glutathione peroxidase (GPx) which converts Glutathione to its oxidized form "GSSG" and glutathione reductase (GR) - which reduces "GSSG" back to Glutathione "GSH".
Glutathione has a profound role in the brain as a detoxifying agent because of the brain's vulnerability towards oxidative stress (as it utilizes 20% of the O2 consumed by the body whereas constitutes only 2% of body weight). Depleted levels of Glutathione is implicated in the cell death in various neurological diseases like Alzheimer’s disease, Parkinson’s disease, and Multiple Sclerosis and for this reason our Naturopathic doctors use Glutathione therapy in these diseases. An interesting case report was published in 2018 detailing a Parkinson's patient with reasonable benefit from moderate dose Glutathione Therapy. The large spike in blood Glutathione that occurs with Glutathione Therapy is thought to move more Glutathione into the brain. Our Edmonton Clinic has given thousands of Glutathione Therapy treatments for various conditions. Glutathione does have some cosmetic benefits in some patients when given - so occasionally our Naturopathic doctors use Glutathione Therapy for cosmetic "brightening" and "lightening" purposes. In a 2012 study, medical students were given either glutathione or placebo for 4 weeks and a lightening of the skin was seen (the melanin indices decreased consistently) in those who received glutathione. Glutathione Uses:
Glutathione In-Depth:Glutathione is found in the cytosol of all mammalian tissues Glutathione is synthesized using constituent amino acids Glutamine, Cysteine and Glycine therefore our Naturopathic doctors often recommend acetylated Cysteine or "NAC" to increase Glutathione orally. Glutathione is synthesized in all cell types with the maximum Glutathione synthesized and exported from the liver. Glutathione is also responsible for detoxification of xenobiotics, either directly by conjugating or acting as a substrate in conjugation reactions for this reason our Naturopaths often use Glutathione or its precursors to "improve" liver function or aid in hormone removal. GSH is known to cross the Blood Brain Barrier through Na-dependent Glutathione transporter. So Glutathione Therapy administration can certainly increase nervous system levels of Glutathione hence the use of Glutathione Therapy in neurological disorders. In the brain, Glutathione neutralizes of redox-active metals like copper and iron as metal induced toxicity and interactions with cellular components have been associated with neurodegenerative disorders. Glutathione is involved in the maintenance of optimal cytokine levels. Pro-inflammatory cytokines like tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β) and IL-6 reduce with Glutathione administration therefore our Naturopaths also like Glutathione Therapy in Autoimmune diseases hence its use in MS. Some data emerged in 2020 linking low levels of Glutathione to the serious manifestations of COVID-19 and case reports use Glutathione therapy for improving COVID outcomes. Glutathione is easily added to the end of other Vitamin Therapy treatments. Most commonly our Naturopaths add Glutathione to Vitamin Therapy or NAD Therapy treatments. Curious about Glutathione?Give us a shout
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